Myoglobin release in rhabdomyolysis damages which organ?

Myoglobin release in rhabdomyolysis damages which organ?

• A. Heart
• B. Lungs
• C. Kidneys
• D. Liver

Answer: (C)

When muscle tissue breaks down in rhabdomyolysis, the released myoglobin travels to the kidneys and can cause injury there. Myoglobin is filtered by the glomeruli and, in large amounts, can accumulate in the renal tubules, forming casts and exerting direct toxic effects on tubular cells. This combination leads to acute kidney injury, especially with dehydration or acid urine. That’s why the kidneys are the organ primarily damaged in this scenario. The heart, lungs, and liver aren’t the primary targets of myoglobin toxicity in rhabdomyolysis, though electrolyte disturbances and other systemic effects can stress these organs.

When muscle tissue breaks down in rhabdomyolysis, the released myoglobin travels to the kidneys and can cause injury there. Myoglobin is filtered by the glomeruli and, in large amounts, can accumulate in the renal tubules, forming casts and exerting direct toxic effects on tubular cells. This combination leads to acute kidney injury, especially with dehydration or acid urine. That’s why the kidneys are the organ primarily damaged in this scenario.

The heart, lungs, and liver aren’t the primary targets of myoglobin toxicity in rhabdomyolysis, though electrolyte disturbances and other systemic effects can stress these organs.